Cairo Homes under $350,000

Welcome to Cairo, Missouri – a charming gem nestled in Randolph County, where small-town charm meets the serene beauty of the Midwest. With its rich history and welcoming community, Cairo offers residents a peaceful lifestyle while still being conveniently located near larger urban centers.

Cairo is known for its friendly atmosphere, making it an ideal place for families, retirees, and anyone seeking a close-knit community. The area boasts a variety of local parks and recreational facilities, perfect for outdoor enthusiasts and families looking to enjoy nature. From leisurely strolls along scenic trails to vibrant community events, Cairo has something for everyone.

For those considering making Cairo their home, you’ll be pleased to discover a selection of beautiful homes available for under $350,000. Whether you’re seeking a cozy starter home, a charming cottage, or a spacious family residence, Cairo offers a diverse range of properties that cater to various lifestyles and preferences. Many homes in this price range feature modern amenities, comfortable layouts, and even some with picturesque views of the surrounding countryside.

Living in Cairo means you can enjoy the tranquility of rural life while still having access to essential amenities, including schools, shopping, and dining options. With a strong sense of community and a commitment to preserving its rich heritage, Cairo is a place where you can truly feel at home. Come explore the possibilities and discover your dream home in this delightful Missouri town!

Newest Cairo Homes under $350,000

$260,000

2 Beds ⋅ 2 Baths ⋅ 26-406 MLS

Great location for this charming 2-bedroom, 2-bath shop house just outside Cairo, MO. Eye-catching interior finishes include open shelving in kitchen and bathrooms, a live-edge mantel, and cable railing on the stairs. All appliances, including the washer and dryer, convey with the property. The shop features its own mini-split system, 16-foot ceilings, and a 14-foot overhead door, providing plenty of space for projects, storage, or equipment. The home is heated and cooled by multiple mini-split units. The spacious lot offers excellent flexibility, with room to build a second home while keeping the existing property as a shop, or expand the current shop house for an even larger footprint. A unique property with plenty of possibilities!

2164 County Road 1390, Cairo

Courtesy of Weichert, Realtors-House of Brokers 573-256-8601

$260,000

2 Beds ⋅ 2 Baths ⋅ 436658 MLS

2164 COUNTY ROAD 1390, Cairo

Courtesy of Weichert, Realtors - House of Brokers

$348,900

4 Beds ⋅ 2 Baths ⋅ 26-279 MLS

Welcome to Briarwood Estates in Cairo! Situated on approximately 5 scenic acres just outside of town, this beautiful 4-bedroom, 2-bath home offers the perfect mix of modern style and comfortable living. Built in 2017, the home features an open-concept layout with contemporary finishes and a warm, inviting feel throughout. All living space is conveniently located on one level, offering both comfort and functionality. Spacious living and kitchen areas are perfect for entertaining, while the generously sized bedrooms provide plenty of room for family and guests. Enjoy peaceful country living with the convenience of being just minutes from town. An oversized attached 2-car garage offers extra storage and workspace. Don't miss this opportunity for modern living with room to roam!

1987 County Road 1620, Cairo

Courtesy of Weichert, Realtors-House of Brokers 573-256-8601

$299,900

3 Beds ⋅ 1 Baths ⋅ 26-267 MLS

Enjoy lake life in this move-in ready 3-bedroom, 1-bath home on the big lake at Holiday Acres near Cairo, MO, between Moberly and Macon. Recent updates include a metal roof, flooring, mini-split units, and a dock built in 2022. Relax on the multi-level front deck overlooking the lake or gather around the waterside firepit. The dock features lifts for a boat, jet skis, and kayaks, plus ample seating space. Home furnishings, outdoor furniture, boat, and jet skis are negotiable.

425 W Shore Dr, Cairo

Courtesy of Weichert, Realtors-House of Brokers 573-256-8601

$348,900

4 Beds ⋅ 2 Baths ⋅ 434958 MLS

1987 COUNTY ROAD 1620, Cairo

Courtesy of Weichert, Realtors - House of Brokers

$299,900

3 Beds ⋅ 1 Baths ⋅ 434765 MLS

425 W SHORE DR, Cairo

Courtesy of Weichert, Realtors - House of Brokers

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Listing information is provided courtesy of the Broker Reciprocity/IDX of Bagnell Dam Association of REALTORS® and Lake of the Ozarks Board of REALTORS®, Inc. Multiple Listing Services. Copyright 2026 Multiple Listing Service, Inc. of Bagnell Dam Association of REALTORS® MLS, Inc. and Lake of the Ozarks Board of REALTORS® MLS, Inc. Information is being provided for consumers’ personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Information herein is believed to be accurate and timely, but no warranty as such is expressed or implied. 2026 Century 21 Community